A correlation between versican and neurofilament expression patterns during the development and adult cycling of rat vibrissa follicles.

S J Harris; C A Jahoda

doi:10.1016/s0925-4773(00)00561-x

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A correlation between versican and neurofilament expression patterns during the development and adult cycling of rat vibrissa follicles.

S J Harris·C A Jahoda

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Abstract

Versican, a proteoglycan recently implicated in hair follicle induction, has been shown to influence axon outgrowth in vitro and in vivo. We used immunohistochemistry to study the relationship between versican expression and innervation, during rat vibrissa follicle development and the adult hair cycle. During development, nerve fibres were commonly associated with areas of weak versican expression, and the path of axons appeared to be delineated by sharp boundaries of versican expression. Versican expression changed in the lower follicle dermis during the adult hair follicle cycle but remained strong around the follicle neck reflecting the constant innervation. Our observations show a correlation between versican expression and peripheral innervation indicating that versican may have a dual role in hair follicle biology.

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Animals Animals, Newborn Axons Chondroitin Sulfate Proteoglycans Hair Follicle Immunohistochemistry Lectins, C-Type Neurofilament Proteins Rats Time Factors Tissue Distribution Versicans Vibrissae Journal Article Research Support, Non-U.S. Gov't

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S J Harris, C A Jahoda. 2001. A correlation between versican and neurofilament expression patterns during the development and adult cycling of rat vibrissa follicles.. https://doi.org/10.1016/s0925-4773(00)00561-x

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