Complementary 'bottom-up' and 'top-down' approaches to basal ganglia function.

D J Perkel; M A Farries

doi:10.1016/s0959-4388(00)00156-2

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Complementary 'bottom-up' and 'top-down' approaches to basal ganglia function.

D J Perkel·M A Farries

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Abstract

Recently, two quite different approaches exemplifying 'bottom-up' and 'top-down' philosophies have shed new light on basal ganglia function. In vitro work using organotypic co-cultures has implicated the subthalamic nucleus (STN) and the external segment of the globus pallidus (GP(e)) as pacemakers for low-frequency bursting that is reminiscent of the activity produced in Parkinsonian tremor. A circuit essential for avian song learning has been identified as part of the basal ganglia with surprisingly well conserved cellular details; investigation of this system may help to address general issues of basal ganglia function.

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Animals Basal Ganglia Movement Songbirds Vocalization, Animal Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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D J Perkel, M A Farries. 2000. Complementary 'bottom-up' and 'top-down' approaches to basal ganglia function.. https://doi.org/10.1016/s0959-4388(00)00156-2

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