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PubMed · 11242632

[Molecule targeted therapy for hematological malignancies].

T Naoe
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Abstract

Over the past 20 years, there has been a marked increase in our knowledge of the molecular mechanisms of human hematological malignancies. The development of mechanism-based therapy is expected to extend the frontiers of chemotherapy. All-trans retinoic acid (ATRA) therapy for acute promyelocytic leukemia (APL), initially established as differentiation therapy, has been recognized to target PML-RAR alpha protein, an APL-specific chimeric transcriptional factor, and to modulate the function. Recently, encouraging results have emerged in the treatment of chronic myeloid leukemia with a tyrosine-kinase inhibitor. In addition to the oncoprotein-targeted therapy, the clinical effectiveness of humanized monoclonal antibodies to differentiation antigens has been recognized. Molecule-targeted therapy is reviewed herein.

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Antibodies, MonoclonalHumansLeukemia, Promyelocytic, AcuteProtein-Tyrosine KinasesTretinoinEnglish AbstractJournal ArticleReview

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T Naoe. 2001. [Molecule targeted therapy for hematological malignancies].. https://pubmed.ncbi.nlm.nih.gov/11242632/

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