Triplex-forming molecules for modulation of DNA information processing.

C Giovannangeli; C Hélène

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PubMed · 11249623

Triplex-forming molecules for modulation of DNA information processing.

C Giovannangeli·C Hélène

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Abstract

The design of specific DNA ligands is an important challenge in biological and biomedical sciences. Targeting the source of genetic information may allow highly efficient gene-directed modulation of cell function. Triplex-forming molecules specifically recognize oligopyrimidine/oligopurine sequences by hydrogen bonding interactions. In cell cultures they have been used successfully to downregulate or upregulate transcription in a gene-specific manner or to induce site-directed mutagenesis and recombination. For biotechnological applications, triplex-forming molecules are powerful tools for gene-specific chemistry.

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Animals Cell Nucleus DNA DNA Damage Humans Ligands Mutagenesis, Site-Directed Nucleic Acid Conformation Oligonucleotides Peptide Nucleic Acids Recombination, Genetic Transcription, Genetic Transcriptional Activation Journal Article Research Support, Non-U.S. Gov't Review

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C Giovannangeli, C Hélène. 2000. Triplex-forming molecules for modulation of DNA information processing.. https://pubmed.ncbi.nlm.nih.gov/11249623/

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