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PubMed · 11249672

Technology evaluation: StealthVector (HIV) Enzo.

W Günzburg·A M Mhashilkar·M Hindi
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Abstract

Efficient inhibition of human immunodeficiency virus-1 (HIV-1) replication with intracellularly expressed antiviral genes would be an important step toward clinical gene therapy for HIV-1 disease. Enzo Biochem is investigating and developing antisense genes as a potential gene therapy approach against a variety of conditions including acquired immunodeficiency syndrome (AIDS), cancer and hepatitis. The subsidiary of Enzo Biochem, Enzo Therapeutics, utilized its StealthVector technology and initiated phase I trials in July 1998 [291511,307156]. StealthVector, which is comprised of independent antisense sequences directed against two functional HIV-1 regions, is involved in regulation of gene expression soon after HIV infection, transactivation response (TAR) and tat/rev. StealthVector localizes primarily in the cell nucleus, where it could be most effective in inhibiting viral growth.

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BiotechnologyDNA, AntisenseGenetic TherapyGenetic VectorsHIV InfectionsHIV-1HumansClinical TrialClinical Trial, Phase IJournal ArticleReview

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W Günzburg, A M Mhashilkar, M Hindi. 1999. Technology evaluation: StealthVector (HIV) Enzo.. https://pubmed.ncbi.nlm.nih.gov/11249672/

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