Technology evaluation: naked DNA.

Y Ilan

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PubMed · 11249676

Technology evaluation: naked DNA.

Y Ilan

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Abstract

Vical and Merck are investigating vaccines against hepatitis B which use Vical's patented naked DNA technology. Both therapeutic and prophylactic vaccines are under development [177132], [268397]. The technology, and subsequent collaboration, stems from the observation by Vical that by directly injecting exogenous cDNA into muscle tissue, protein is expressed which gives rise to a strong immune response and protective immunity [163222].

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Animals Biotechnology Clinical Trials as Topic Genetic Therapy Hepatitis B Hepatitis B Vaccines Humans Mice T-Lymphocytes, Cytotoxic Vaccines, DNA Evaluation Study Journal Article Review

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Y Ilan. 1999. Technology evaluation: naked DNA.. https://pubmed.ncbi.nlm.nih.gov/11249676/

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