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PubMed · 11249749

Technology evaluation: CN-706, Calydon Inc.

C Doehn·D Jocham
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Abstract

CN-706, an engineered adenovirus containing the prostate tissue-specific enhancer (PSE) gene is under development by Calydon as a potential treatment for prostate cancer. The company is collaborating with the Johns Hopkins Hospital, which has agreed to sponsor clinical trials [274956]. Phase I trials in patients with advanced and recurring prostate cancer began during 1998 at the Johns Hopkins Brady Urological Institute and the Oncology Center [283946], [296857], and the results of phase I/II trials were reported in 2000 [386879]. The US Patent Office issued three patents in October 1998 [301251] related to Calydon's technology for engineering viruses to replicate and kill prostate cancer cells [US-05648478], [US-05698443], [US-05783435]. In June 1999, Calydon was issued two further patents [US-05871726], [US-05830686], [327511].

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AdenoviridaeAnimalsBiotechnologyGenetic TherapyGenetic VectorsHumansMaleMiceProstate-Specific AntigenProstatic NeoplasmsTumor Cells, CulturedClinical TrialClinical Trial, Phase IClinical Trial, Phase IIJournal ArticleReview

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C Doehn, D Jocham. 2000. Technology evaluation: CN-706, Calydon Inc.. https://pubmed.ncbi.nlm.nih.gov/11249749/

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