Technology evaluation: edrecolomab, Centocor Inc.

A Abicht; H Lochmüller

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PubMed · 11249762

Technology evaluation: edrecolomab, Centocor Inc.

A Abicht·H Lochmüller

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Abstract

Specific targeting of tumor cells may be achieved by using monoclonal antibodies to tumor antigens. Edrecolomab is a mouse-derived monoclonal IGg2A antibody directed against the human tumor-associated CO17-1A (or Ep-CAM) antigen, and is the first monoclonal antibody approved for cancer therapy. Encouraging results of several clinical trials were recently reported using edrecolomab for adjuvant therapy after surgery of Duke's C colorectal cancer. Side effects and toxicity profiles compare favorably to conventional regimens of radio- or chemotherapy. Future challenges lie in further improvement of these novel therapeutics, hopefully generating benefit for a larger number of cancer patients.

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Animals Antibodies, Monoclonal Antibodies, Neoplasm Antigens, Neoplasm Biotechnology Colorectal Neoplasms Combined Modality Therapy Humans Immunotherapy Interferon-gamma Mice Neoplasms Recombinant Proteins Clinical Trial Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Journal Article Review

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A Abicht, H Lochmüller. 2000. Technology evaluation: edrecolomab, Centocor Inc.. https://pubmed.ncbi.nlm.nih.gov/11249762/

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