Technology evaluation: GEM-231, Hybridon Inc.

J Blay

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PubMed · 11249779

Technology evaluation: GEM-231, Hybridon Inc.

J Blay

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Abstract

Hybridon is conducting studies of the DNA methyltransferase gene and has identified specific sequences on mRNA as targets for chemically-modified antisense oligonucleotides. Hybridon has synthesized compounds that alter methylation of cultured human cancer cells and inhibit their ability to grow in cell culture and inhibit tumor formation in mice [191303]. The work is being carried out in collaboration with McGill University in Montreal and as part of a joint venture called MethylGene, set up by Hybridon and private investors. GEM-231 (a mixed backbone oligonucleotide) is a strand of synthetic DNA, which has been modified with 2'-O-methyl ribose at both ends in order to resemble RNA. It has the ability to inhibit expression of the R1-alpha subunit of protein kinase A, a gene whose expression has been associated with many types of cancer [273331,275860].

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Animals Biotechnology Cyclic AMP-Dependent Protein Kinases Enzyme Inhibitors Female Humans Mice Neoplasms Oligonucleotides, Antisense Tumor Cells, Cultured Clinical Trial Clinical Trial, Phase I Clinical Trial, Phase II Journal Article Review

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J Blay. 2000. Technology evaluation: GEM-231, Hybridon Inc.. https://pubmed.ncbi.nlm.nih.gov/11249779/

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