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Histone acetyltransferases: function, structure, and catalysis.

R Marmorstein·S Y Roth
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Abstract

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT mutations, further highlighting the importance of these enzymes to normal cell growth and differentiation.

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AcetylationAcetyltransferasesAnimalsCatalysisChromatinEmbryonic and Fetal DevelopmentHistone AcetyltransferasesHistonesHumansMiceNeoplasmsSaccharomyces cerevisiae ProteinsTranscription, GeneticYeastsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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R Marmorstein, S Y Roth. 2001. Histone acetyltransferases: function, structure, and catalysis.. https://doi.org/10.1016/s0959-437x(00)00173-8

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