Replication checkpoint: preventing mitotic catastrophe.

C E Canman

doi:10.1016/s0960-9822(01)00057-4

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Replication checkpoint: preventing mitotic catastrophe.

C E Canman

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Abstract

A conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is detrimental to the developing embryo. Recent studies have shed new light on how the essential ATR and Chk1 protein kinases cooperate to prevent such a crisis.

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Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage DNA Polymerase I DNA Replication DNA-Binding Proteins Humans Mitosis Proliferating Cell Nuclear Antigen Protein Kinases Protein Serine-Threonine Kinases Schizosaccharomyces pombe Proteins Signal Transduction Tumor Suppressor Proteins Journal Article Review

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C E Canman. 2001-02-20. Replication checkpoint: preventing mitotic catastrophe.. https://doi.org/10.1016/s0960-9822(01)00057-4

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