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Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs.

L Ferraro·S Tanganelli·K Fuxe·B W Bebe·M C Tomasini·F A Rambert·T Antonelli
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Abstract

Modafinil did not affect spontaneous and K(+)-evoked [3H]5-HT efflux from cortical synaptosomes while it increased K(+)-evoked tritium efflux from cortical slices, an action that became stronger in the presence of paroxetine. In contrast, DL-fenfluramine and fluoxetine were able to enhance spontaneous and/or K(+)-evoked tritium efflux from synaptosomes and slices. These results suggest that modafinil does not affect 5-HT transmission from cortical synaptosomes and that its 5-HT releasing action is different from that of DL-fenfluramine and fluoxetine.

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AnimalsBenzhydryl CompoundsFenfluramineFluoxetineFrontal LobeIn Vitro TechniquesMaleModafinilNeuroprotective AgentsParoxetinePotassiumRatsRats, Sprague-DawleySerotoninSelective Serotonin Reuptake InhibitorsSleepSynaptic TransmissionSynaptosomesTritiumComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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L Ferraro, S Tanganelli, K Fuxe, B W Bebe, M C Tomasini, F A Rambert, T Antonelli. 2001-03-16. Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs.. https://doi.org/10.1016/s0006-8993(01)02000-5

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