Complement and IL-12: yin and yang.

C L Karp; M Wills-Karp

doi:10.1016/s1286-4579(00)01358-7

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Complement and IL-12: yin and yang.

C L Karp·M Wills-Karp

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Abstract

Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here.

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Animals Asthma Complement System Proteins Gene Expression Regulation Humans Interleukin-12 Measles Monocytes Journal Article Research Support, U.S. Gov't, P.H.S.Review

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C L Karp, M Wills-Karp. 2001. Complement and IL-12: yin and yang.. https://doi.org/10.1016/s1286-4579(00)01358-7

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