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PubMed · 11257451

Receptor activity modifying proteins.

P M Sexton·A Albiston·M Morfis·N Tilakaratne
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Abstract

Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. A similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current state of knowledge of the mechanisms underlying RAMP function.

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Amino Acid SequenceAnimalsCell LineDimerizationGlycosylationHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMicroscopy, ConfocalModels, BiologicalModels, GeneticMolecular Sequence DataPeptidesPhenotypeProtein BindingProtein Structure, TertiaryRatsReceptor Activity-Modifying ProteinsReceptors, CalcitoninReceptors, Cell SurfaceSequence Homology, Amino AcidTissue DistributionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P M Sexton, A Albiston, M Morfis, N Tilakaratne. 2001. Receptor activity modifying proteins.. https://doi.org/10.1016/s0898-6568(00)00143-1

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