The TIM-barrel fold: a versatile framework for efficient enzymes.

R K Wierenga

doi:10.1016/s0014-5793(01)02236-0

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The TIM-barrel fold: a versatile framework for efficient enzymes.

R K Wierenga

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Abstract

Recent studies on triosephosphate isomerase (TIM)-barrel enzymes highlight the remarkable versatility of the TIM-barrel scaffold. At least 15 distinct enzyme families use this framework to generate the appropriate active site geometry, always at the C-terminal end of the eight parallel beta-strands of the barrel. Sequence and structure comparisons now suggest that many of the TIM-barrel enzymes are evolutionarily related. Common structural properties of TIM-barrel enzymes are discussed.

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Binding Sites Escherichia coli Evolution, Molecular Models, Molecular Protein Conformation Triose-Phosphate Isomerase Journal Article Review

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R K Wierenga. 2001-03-16. The TIM-barrel fold: a versatile framework for efficient enzymes.. https://doi.org/10.1016/s0014-5793(01)02236-0

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