CD28 and T cell co-stimulation.

A D Holdorf; O Kanagawa; A S Shaw

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PubMed · 11258416

CD28 and T cell co-stimulation.

A D Holdorf·O Kanagawa·A S Shaw

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Abstract

Over the last decade the concept of T cell co-stimulation has emerged to take a central role in the process of T cell activation. However, the exact definition of co-stimulation is still unclear. In this review, we re-examine the concept of co-stimulation. We suggest that while co-stimulation is important, there is little evidence to link co-stimulation with T cell anergy. We then suggest a framework for studying co-stimulation. Focusing on recent advances in our understanding of CD28, we discuss four areas of T cell activation where co-stimulation may play a role.

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Animals CD28 Antigens Cell Survival Humans Interleukin-2 Lymphocyte Activation Mice NF-kappa B Promoter Regions, Genetic Signal Transduction T-Lymphocytes Journal Article Review

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A D Holdorf, O Kanagawa, A S Shaw. 2000. CD28 and T cell co-stimulation.. https://pubmed.ncbi.nlm.nih.gov/11258416/

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