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PubMed · 11258518

An efficient batch preparation of high specific activity.

J K Amartey·I Al-Jammaz·R M Lambrecht
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Abstract

The increasing demand for radiolabeled metaiodobenzylguanidine (mIBG) prompted the need to obtain the radiopharmaceutical by a reliable, routine and simple synthetic method for batch production. The production of mIBG labeled with either 123I or 124I has been optimized by modifying literature methods that involve solid-state exchange reaction on "cold" mIBG facilitated by ammonium sulfate. The radiochemical yield and purity of radioiodinated mIBG generally exceeded 80 and 98%, respectively, with specific activity of > 50 mCi/mg.

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3-IodobenzylguanidineAmmonium SulfateIndicators and ReagentsIodine RadioisotopesRadiopharmaceuticalsJournal ArticleResearch Support, Non-U.S. Gov't

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J K Amartey, I Al-Jammaz, R M Lambrecht. 2001. An efficient batch preparation of high specific activity.. https://doi.org/10.1016/s0969-8043(00)00340-7

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