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Solution structure of (+)-discodermolide.

A B Smith·M J LaMarche·M Falcone-Hindley
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Abstract

[structure: see text]. The solution structure of (+)-discodermolide (1) has been determined via 1- and 2-D NMR techniques in conjunction with Monte Carlo conformational analysis. Taken together, the results demonstrate that in solution (+)-discodermolide occupies a helical conformation remarkably similar to the solid state conformation.

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AlkanesAnimalsCarbamatesImmunosuppressive AgentsLactonesMagnetic Resonance SpectroscopyMass SpectrometryModels, MolecularMonte Carlo MethodPoriferaPyronesSolutionsTubulinJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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A B Smith, M J LaMarche, M Falcone-Hindley. 2001-03-08. Solution structure of (+)-discodermolide.. https://doi.org/10.1021/ol006967p

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