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PubMed · 11267164

Polyclonal antibodies in immunosuppression.

D C Brennan
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Antilymphocyte SerumClinical Trials as TopicGraft RejectionHumansImmunosuppressive AgentsOrgan TransplantationJournal Article

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D C Brennan. Polyclonal antibodies in immunosuppression.. https://doi.org/10.1016/s0041-1345(00)02304-6

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Allogeneic stem cell transplantation in a patient with dyskeratosis congenita after conditioning with low-dose cyclophosphamide and anti-thymocyte globulin.

Bone marrow failure is the major cause of early mortality in patients with dyskeratosis congenita (DC); early trials with conventional conditioning regimens were associated with remarkable chronic morbidity and mortality, and the optimal conditioning regimen for these patients remains undetermined. We report a case of a child afflicted with DC who underwent related full HLA-matched stem cell transplant (SCT) using a regimen of low dose cyclophosphamide and antithymocyte globulin (ATG). The regimen was well tolerated and associated with no significant short-term toxicity.

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