Remote F-wave changes after local botulinum toxin application.

K Wohlfarth; M Schubert; B Rothe; J Elek; R Dengler

doi:10.1016/s1388-2457(01)00478-3

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Remote F-wave changes after local botulinum toxin application.

K Wohlfarth·M Schubert·B Rothe·J Elek·R Dengler

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Abstract

OBJECTIVE: Although the therapeutic effects of botulinum toxin A can be explained by its action at the neuromuscular junction, central or more proximal effects have also been discussed. METHODS: Eleven patients with torticollis spasmodicus and 3 patients with writer's cramp were studied before and 1 and 5 weeks after the first treatment with botulinum toxin. We measured compound muscle action potentials (CMAPs), motor conduction velocities (MCVs), the shortest (SFL) and the mean F-wave latencies (MFL) and F-wave persistence (30 trials) of untreated muscles for each side (ulnar nerve-abductor digiti minimi muscle, peroneal nerve-tibialis anterior muscle). RESULTS: CMAPs and MCVs showed no significant changes. For both nerves, however, SFL and MFL were prolonged slightly 1 week after treatment and returned to about baseline after 5 weeks (t test). The F-wave persistence was reduced 1 week after treatment for the right ulnar and both peroneal nerves (t test). CONCLUSIONS: These results are not likely due to an impairment of neuromuscular transmission. Instead, we propose a decreased excitability of alpha-motoneurons supplying non-treated muscles. A reduction of muscle spindle activity or changes of the recurrent inhibition are discussed as possible causes.

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Action Potentials Adult Botulinum Toxins, Type A Dystonic Disorders Female Humans Male Middle Aged Muscle Contraction Muscle, Skeletal Peroneal Nerve Time Factors Torticollis Ulnar Nerve Journal Article

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K Wohlfarth, M Schubert, B Rothe, J Elek, R Dengler. 2001. Remote F-wave changes after local botulinum toxin application.. https://doi.org/10.1016/s1388-2457(01)00478-3

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