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PubMed · 1127993

Drug-induced malabsorption.

G F Longstreth·A D Newcomer
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Abstract

Pharmacologic agents of diverse types may alter gastrointestinal absorption of nutrients and other substances. Mechanisms underlying drug-induced absorptive defects that have been documented include: (1) a direct toxic effect causing morphologic changes in the mucosa of the small intestine; (2) inhibition of mucosal enzymes with or without morphologic evidence of mucosal damage; (3) binding and precipitation of micellar components, such as bile acids and fatty acids; and (4) alteration of the physicochemical state of another drug or dietary ion. The malabsorptive effect generally is dose-related, rather than an idiosyncratic reaction, and usually involves multiple nutrients. Certain clinical states, such as in the malnourished alcoholic may predipose the gastrointestinal tract to a drug-induced absorptive defect. For this review we discuss in detail nine commonly used drugs or types of drugs that cause malabsorption of dietary nutrients or other medications.

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AlcoholismAminosalicylic AcidsAntacidsBiguanidesCatharticsCholestyramine ResinColchicineContraceptives, OralDose-Response Relationship, DrugEthanolFemaleHumansIntestinal MucosaMalabsorption SyndromesNeomycinJournal Article

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G F Longstreth, A D Newcomer. 1975. Drug-induced malabsorption.. https://pubmed.ncbi.nlm.nih.gov/1127993/

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