Designing metal-peptide models for protein structure and function.

G Xing; V J DeRose

doi:10.1016/s1367-5931(00)00190-3

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Designing metal-peptide models for protein structure and function.

G Xing·V J DeRose

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Abstract

Recent progress in the rational design of metal sites within peptide model systems shows increasing control in the placement of metals within helical bundles and inclusion of sophisticated elements such as second-sphere ligand interactions. A crystallographically characterized two-metal peptide model for diiron proteins represents a major achievement in de novo design methodologies. Increasingly complex and robust models for electron transfer through and between helices, and electrode-supported electron-transfer peptides, have been constructed. Design elements for peptide-supported ferredoxins and mononuclear Fe(II) and Zn(II) sites have been refined.

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Amino Acid Sequence Binding Sites Crystallography Electron Transport Ferredoxins Ligands Metals Models, Chemical Molecular Structure Peptides Protein Structure, Secondary Proteins Journal Article Research Support, Non-U.S. Gov't Review

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G Xing, V J DeRose. 2001. Designing metal-peptide models for protein structure and function.. https://doi.org/10.1016/s1367-5931(00)00190-3

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