Notch1 and T-cell development: insights from conditional knockout mice.

H R MacDonald; A Wilson; F Radtke

doi:10.1016/s1471-4906(00)01828-7

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Notch1 and T-cell development: insights from conditional knockout mice.

H R MacDonald·A Wilson·F Radtke

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Abstract

Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.

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Animals B-Lymphocytes CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Differentiation Cell Lineage Membrane Proteins Mice Mice, Knockout Receptor, Notch1 Receptors, Antigen, T-Cell, alpha-beta Receptors, Antigen, T-Cell, gamma-delta Receptors, Cell Surface Signal Transduction T-Lymphocytes Transcription Factors Journal Article Review

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H R MacDonald, A Wilson, F Radtke. 2001. Notch1 and T-cell development: insights from conditional knockout mice.. https://doi.org/10.1016/s1471-4906(00)01828-7

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