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HuR and mRNA stability.

C M Brennan·J A Steitz
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Abstract

An important mechanism of posttranscriptional gene regulation in mammalian cells is the rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in their 3' untranslated regions. HuR, a ubiquitously expressed member of the Hu family of RNA-binding proteins related to Drosophila ELAV, selectively binds AREs and stabilizes ARE-containing mRNAs when overexpressed in cultured cells. This review discusses mRNA decay as a general form of gene regulation, decay signaled by AREs, and the role of HuR and its Hu-family relatives in antagonizing this mRNA degradation pathway. The influence of newly identified protein ligands to HuR on HuR function in both normal and stressed cells may explain how ARE-mediated mRNA decay is regulated in response to environmental change.

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Amino Acid SequenceAnimalsAntigens, SurfaceBase SequenceBiological Transport, ActiveCarrier ProteinsCell DifferentiationCytoplasmELAV ProteinsELAV-Like Protein 1HumansModels, BiologicalMolecular Sequence DataRNA StabilityRNA, MessengerRNA-Binding ProteinsSequence Homology, Amino AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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C M Brennan, J A Steitz. 2001. HuR and mRNA stability.. https://doi.org/10.1007/pl00000854

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