Hypothesis: pulse pressure and human longevity.

A Aviv

doi:10.1161/01.hyp.37.4.1060

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Hypothesis: pulse pressure and human longevity.

A Aviv

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Abstract

In exploration of the association between pulse pressure and longevity in humans, 3 hypotheses are briefly discussed: the fetal origin hypothesis, antagonistic pleiotropy, and the telomere hypothesis of cellular aging. The implications of these hypotheses serve to draw a critical distinction between biologic age (aging) and chronological age and, thereby, offer an answer to a question that presently matters most in the field of hypertension: Why has it been so difficult to disentangle the genetic components of essential hypertension and to identify the variant genes responsible for elevated blood pressure in a large segment of the human population?

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Aging Animals Cellular Senescence Female Humans Hypertension Longevity Male Menopause Pulse Risk Factors Telomere Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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A Aviv. 2001. Hypothesis: pulse pressure and human longevity.. https://doi.org/10.1161/01.hyp.37.4.1060

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