PubMed · 11307528
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N Hayashi. 2001-03-10. [Chronic viral liver dysfunction].. https://pubmed.ncbi.nlm.nih.gov/11307528/
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Chronic hepatitis B remains one of the most wide-spread and serious viral infections in humans worldwide and may lead to cirrhosis and cancer of the liver. Eradication of the virus depends primarily on T-cell immune reaction aimed at lysis of the infected hepatosytes and suppression of the virus replication without cell death due to secretion of proinflammatory cytokines. Pathogenesis of the disease is markedly influenced by viral mutations. Persistent hepatitis B virus infection can be controlled in 25-40% patients by alpha-interferon and nucleoside lamivudine therapy.