Introduction and overview. Statistical methods in genetic epidemiology.

R C Elston

doi:10.1177/096228020000900602

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Introduction and overview. Statistical methods in genetic epidemiology.

R C Elston

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Abstract

Common terms used in genetics with multiple meanings are explained and a brief overview given of the four major areas of genetic epidemiology--the study of familial aggregation, segregation, cosegregation and association. Familial aggregation measures the potential for a trait to have a genetic aetiology. Segregation analysis uncovers single gene segregation. Cosegregation with genetic markers gives rise to linkage, which is used to locate trait genes on the genome. Association analysis is used for fine mapping, but rests on the assumption that linkage disequilibrium exists.

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Chromosome Mapping Chromosome Segregation Epidemiologic Methods Genetic Predisposition to Disease Genetics, Medical Genotype Humans Phenotype Statistics as Topic Terminology as Topic Journal Article Research Support, U.S. Gov't, P.H.S.Review

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R C Elston. 2000. Introduction and overview. Statistical methods in genetic epidemiology.. https://doi.org/10.1177/096228020000900602

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