PubMed · 11314201
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
J Collins. 2000. A precise and predictable laboratory procedure for indirect bonding.. https://pubmed.ncbi.nlm.nih.gov/11314201/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
Peptides and more especially insulin are mainly used in therapies that need multiple drug administration. As peptides are highly potent, it is required that their bioavailability remains constant even during a long term administration. In this study, the bioavailability and blood glucose levels are reported after multiple nasal administration of insulin via two bioadhesive platforms consisting of a cospray dried mixture of Amioca starch and Carbopol 974P (1/3) and a physical mixture of drum dried waxy maize starch and Carbopol 974P (9/1), respectively. The experiments were performed in rabbits and the formulations were administered during 8 consecutive days. The bioavailability and the maximal decrease of the blood glucose level were determined on the first and last day of the insulin administration. These two parameters were decreased on the eighth day compared with the first day of administration. When the formulations were not administered from day 2 until day 7, the bioavailability on the eighth day compared with the first day of administration was not modified. It was concluded that daily administrations of the bioadhesive formulations affected the nasal bioavailability of insulin in rabbits.
The influence of rotary peeling on the different behaviour of tight and loose sides of Eucalyptus globulus veneers has been studied. The presence of lathe checks on the loose sides favours wettability, the contact angle decreasing more rapidly on these sides than on tight sides. Additionally, pine bark tannins improved wettability due to their surfactant character. Bonding quality tests carried out on plywoods prepared using a tannin-phenol-formaldehyde adhesive showed that fracture almost invariably occurred in a glue line with at least one loose side, where wood failure appeared. This behaviour, confirmed by analysing the glue lines by means of fluorescence microscopy, was due to the large surface alterations of the loose sides which reduced mechanical strength but allowed greater penetration of the adhesive giving rise to high wood failure.