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PubMed · 11320331

[Developments in anti-malaria agents: chemical data, structure-activity relationships].

M Debaert
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Abstract

Various features of the evolution of a few antimalarial drugs including amodiaquine, dihydrofolate-reductase inhibitors, and artemisinin are described. The mechanism of action of artemisinin is detailed to explain the information of the main metabolites and drug design of certain compounds. Structure-activity and structure-neurotoxicity relations are reported. A few examples of cyclic peroxycetal synthesis are given. Finally, trends in new and novel compounds are presented.

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AmodiaquineAnimalsAntimalarialsArtemisininsDrug ResistanceDrugs, Chinese HerbalFolic Acid AntagonistsPlasmodium falciparumSesquiterpenesStructure-Activity RelationshipJournal ArticleReview

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M Debaert. 2001. [Developments in anti-malaria agents: chemical data, structure-activity relationships].. https://pubmed.ncbi.nlm.nih.gov/11320331/

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