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Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain tumours.

R S Kaatee·P C Nowak·J van der Zee·J de Bree·B P Kanis·H Crezee·P C Levendag·A G Visser
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Abstract

BACKGROUND AND PURPOSE: In interstitial hyperthermia, temperature measurements are mainly performed inside heating applicators, and therefore, give the maximum temperatures of a rather heterogeneous temperature distribution. The problem of how to estimate lesion temperatures using the multi-electrode current-source interstitial hyperthermia (MECS-IHT) system in the brain was studied. MATERIALS AND METHODS: Temperatures were measured within the electrodes and in an extra catheter at the edge of a 4 x 4 x 4.5 cm(3) glioblastoma multiforme resection cavity. From the temperature decays during a power-off period, information was obtained about local maximum and minimum tissue temperatures. The significance of these data was examined through model calculations. RESULTS: Maximum tissue temperatures could be estimated roughly by switching off all electrodes for about 5 s. Model calculations showed that the minimum tissue temperatures near a certain afterloading catheter correspond well with the temperature of the applicator inside, about 1 min after this applicator was switched off. CONCLUSIONS: Although the electrode temperatures read during heating are not suitable to assess the temperature distribution, it is feasible to heat the brain adequately using the MECS-IHT system with extra sensors outside the electrodes and/or application of decay methods.

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Brain NeoplasmsGliomaHumansHyperthermia, InducedThermometersJournal ArticleResearch Support, Non-U.S. Gov't

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R S Kaatee, P C Nowak, J van der Zee, J de Bree, B P Kanis, H Crezee, P C Levendag, A G Visser. 2001. Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain tumours.. https://doi.org/10.1016/s0167-8140(01)00310-3

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