[Chiral ion-pair chromatography].

X Li; S Zeng

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PubMed · 11326980

[Chiral ion-pair chromatography].

X Li·S Zeng

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Abstract

A chiral counter-ion dissolved in the mobile phase can be used to separate enantiomers of acids and amines. The principles and related separation variables have been reviewed. A successful enantiomeric separation is highly dependent on the features of counter-ion chosen for the experiments. The most important properties of a suitable chiral reagent can be summarized as follows: (1) acid-base character of counter-ion; (2) hydrophobicity of counter-ions; (3) presence of suitable functional groups; (4) enantiomeric purity of counter-ion, etc. It is also discussed about the influences of various chromatographic conditions and the applications of chiral ion-pair chromatography.

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Amines Amino Acids Chromatography, High Pressure Liquid Chromatography, Ion Exchange Naphthalenes English Abstract Journal Article Research Support, Non-U.S. Gov't

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X Li, S Zeng. 1998. [Chiral ion-pair chromatography].. https://pubmed.ncbi.nlm.nih.gov/11326980/

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