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PubMed · 11334104

Structure-function relationship of three triple-helical nucleic acids.

A Giacometti
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Abstract

The nucleic acid triplexes poly d(T) x poly d(A) x poly d(T), poly (U) x poly (A) x poly (U), and poly (I) x poly (A) x poly (I) display a sort of continuity between each other. However, their morphologies present their own individuality which, considering those of their parent duplexes, are quite unexpected. This comparison helps to understand triplex structure-function relationship. While helical parameters are functions of the sugar pucker, low values of WC and Hoogsteen base-pair propellers is commonplace for triplexes and the Hoogsteen base-pair geometry monitors the effects of the interstrand phosphates charge-charge repulsion.

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Nucleic Acid ConformationPoly APoly IPoly TPoly UPolynucleotidesStructure-Activity RelationshipJournal Article

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BibTeXRIS

A Giacometti. 2001. Structure-function relationship of three triple-helical nucleic acids.. https://doi.org/10.1080/07391102.2001.10506697

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