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PubMed · 11338933

Hydrodynamics-based gene delivery.

D Liu·J E Knapp
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Abstract

The need for a safe and efficient method for gene delivery has stimulated the recent emergence of vectorless methods (e.g., naked DNA) as promising alternatives to the available viral- and non-viral-based systems. Among these methods, hydrodynamics-based gene delivery through systemic injection of DNA offers a convenient, efficient and powerful means for high-level gene expression in mice. This review deals with the background and progress made so far with this new gene delivery method, the potential mechanism underlying the hydrodynamics-based DNA transfer into cells and its potential applications towards gene function analysis, protein expression and gene therapy in whole animals.

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AnimalsDNAGene Expression RegulationGene Transfer TechniquesGenetic TherapyGenetic VectorsHepatocytesHumansJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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D Liu, J E Knapp. 2001. Hydrodynamics-based gene delivery.. https://pubmed.ncbi.nlm.nih.gov/11338933/

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