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Antigen-specific immunity. Th cell-dependent B cell responses.

M G McHeyzer-Williams·L J McHeyzer-Williams·J Fanelli Panus·G Bikah·R R Pogue-Caley·D J Driver·M D Eisenbraun
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Abstract

Helper T cell-regulated B cell responses constitute a major component of the primary immune response to many pathogens. The subsequent development of antigen-specific immune memory is one critical outcome of this primary adaptive immune response. Antigen-specific immunity develops through a series of intercellular information exchanges organized around cognate T cell receptor-peptide/MHC interactions. Here, we discuss these complex molecularevents andtheircellularconsequences in a serial synapsis model of adaptive immunity. Our laboratory has developed strategies to isolate antigen-specific Th cells and B cells to analyze gene expression and cellular function in single responding lymphocytes directly ex vivo. These studies provide insight into the regulation and cellular organization of antigen-specific immune responses in vivo.

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AnimalsAntigens, Differentiation, T-LymphocyteB-LymphocytesEpitopesHumansImmunity, ActiveImmunologic MemoryT-Lymphocytes, Helper-InducerJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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M G McHeyzer-Williams, L J McHeyzer-Williams, J Fanelli Panus, G Bikah, R R Pogue-Caley, D J Driver, M D Eisenbraun. 2000. Antigen-specific immunity. Th cell-dependent B cell responses.. https://doi.org/10.1385/ir%3A22%3A2-3%3A223

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