Spliceosomal UsnRNP biogenesis, structure and function.

C L Will; R Lührmann

doi:10.1016/s0955-0674(00)00211-8

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Spliceosomal UsnRNP biogenesis, structure and function.

C L Will·R Lührmann

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Abstract

Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.

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Animals Crystallography Humans Macromolecular Substances Protein Structure, Tertiary Protein Transport RNA Splicing RNA, Small Nuclear Ribonucleoprotein, U1 Small Nuclear Ribonucleoproteins, Small Nuclear Spliceosomes Journal Article Research Support, Non-U.S. Gov't Review

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C L Will, R Lührmann. 2001. Spliceosomal UsnRNP biogenesis, structure and function.. https://doi.org/10.1016/s0955-0674(00)00211-8

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