Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats.

G Skuza

PubMed · 11345488

Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats.

Abstract

The obtained results indicate that joint administration of CGP 37849, a competitive NMDA receptor antagonist, and SA4503, a sigma1 (sigma1) receptor agonist or DTG, sigma 1/2 receptor agonist, evoked anticataleptic effect at doses which were ineffective when each of the compounds was given alone.

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2-Amino-5-phosphonovalerate Animals Anticonvulsants Antipsychotic Agents Catalepsy Drug Combinations Excitatory Amino Acid Antagonists Guanidines Haloperidol Male Piperazines Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate Receptors, sigma Spiperone Journal Article

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G Skuza. Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats.. https://pubmed.ncbi.nlm.nih.gov/11345488/

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