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PubMed · 11350192

Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms.

X Yang·R E Pratley·L J Baier·Y Horikawa·G I Bell·C Bogardus·P A Permana
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Abstract

The DNA polymorphism SNP-43 in the calpain-10 gene is associated with insulin resistance and reduced skeletal muscle transcript in Pima Indians. Alternative splicing generates transcript isoforms calpain-10a to -10h. We determined the contribution of calpain-10 mRNA isoforms to the decreased total skeletal muscle calpain-10 mRNA levels observed in the G/G homozygotes. The expression levels of the major isoforms, calpain-10a and -10f, were positively correlated with the total calpain-10 mRNA levels, indicating a cumulative effect.

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CalpainFemaleGenotypeHumansIndians, North AmericanIsoenzymesMaleMuscle, SkeletalPolymorphism, GeneticRNA, MessengerTranscription, GeneticJournal Article

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X Yang, R E Pratley, L J Baier, Y Horikawa, G I Bell, C Bogardus, P A Permana. 2001. Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms.. https://doi.org/10.1006/mgme.2001.3171

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