Syndecans and cell adhesion.

J R Couchman; L Chen; A Woods

doi:10.1016/s0074-7696(01)07004-8

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PubMed · 11352265

Syndecans and cell adhesion.

J R Couchman·L Chen·A Woods

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Abstract

Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.

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Amino Acid Sequence Animals Cell Adhesion Glycosaminoglycans Humans Membrane Glycoproteins Models, Molecular Molecular Sequence Data Phylogeny Protein Structure, Tertiary Proteoglycans Sequence Alignment Signal Transduction Syndecans Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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J R Couchman, L Chen, A Woods. 2001. Syndecans and cell adhesion.. https://doi.org/10.1016/s0074-7696(01)07004-8

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