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PubMed · 1135431

PGE2:PGE-2:.

R Ceserani·C Gandolfi·M M Usardi·M Bergamaschi
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Abstract

The biological activities of 8,12-diiso-PGE2 (ent-11,15-epi-PGE2), PGE2 and PGF2alpha have been compared in a series of pharmacological preparations intended to differentiate between F and E type of activity. Similar to PGF2alpha but unlike PGE2, 8,12-diiso-PGE2 increased the tone of isolated smooth muscle preparations of guinea pig trachea, guinea pig colonic circular layer, rabbit Fallopian tubes. The stimulation effect of 8,12-diiso-PGE2 and PGF2alpha on visceral smooth muscle was also shown in vivo: the two drugs were in all instances able to increase the miogenic activity and tone of rabbit uterus in situ, while these were depressed by PGE2. 8,12-diiso-PGE2 decreased pulmonary compliance and increased pulmonary vascular resistance in the anaesthetized cat; PGE2 always decreased pulmonary vascular resistance, while leaving pulmonary compliance unaltered. The possibility is suggested that 8,12-diiso-PGE2 acts on PGF receptor in different tissues.

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AnimalsCatsColonDepression, ChemicalFallopian TubesFemaleGuinea PigsLungLung ComplianceMaleMuscle TonusMuscle, SmoothProstaglandinsRabbitsStimulation, ChemicalTracheaUterusVascular ResistanceJournal Article

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BibTeXRIS

R Ceserani, C Gandolfi, M M Usardi, M Bergamaschi. 1975. PGE2:PGE-2:.. https://doi.org/10.1016/s0090-6980(75)80121-3

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