PubMed · 11367322
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
J Slovick. 1999. Expanded access program for ABT-378 under way.. https://pubmed.ncbi.nlm.nih.gov/11367322/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The aim of this study was to develop a specific and sensitive high-performance liquid chromatographic (HPLC) assay for the determination of levofloxacin in human plasma, bronchoalveolar lavage and bone tissues. The sample extraction was based on a fully automated liquid-solid extraction with an OASIS cartridge. The method used ultraviolet detection set at a wavelength of 299 nm and a separation with a Supelcosil ABZ+ column. The assay has been found linear over the concentration range 0.25-25 microg/ml for levofloxacin in plasma, 1-6 microg/ml in bronchoalveolar lavage and 0.5-10 microg/g for bone tissues and it provided good validation data for accuracy and precision. The assay will be applied to determine the penetration of levofloxacin in human bronchoalveolar lavage (BAL) and bone tissues during pharmacokinetic steady state.
Explore the source record for details and available documents.
The results of a preliminary antimicrobial screening of the methanol extracts of Aframomum melegueta, Piper guineense, Xylopia aethiopica, Zingiber officinale, medicinal plants of Ghana, are reported.