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PubMed · 11367537

Immunostimulant oxidized beta-glucan conjugates.

G G Cross·H J Jennings·D M Whitfield·C L Penney·B Zacharie·L Gagnon
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Abstract

beta-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many beta-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the beta-Glucan from Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized beta-glucan and its conjugates with O-beta-alanyl-5-[6-(N,N'-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess.

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Adjuvants, ImmunologicAnimalsB-LymphocytesCarbohydrate SequenceFemaleGlucansHumansIn Vitro TechniquesKiller Cells, NaturalMacrophagesMiceMice, Inbred C57BLMolecular Sequence DataOxidation-ReductionSaccharomyces cerevisiaeT-Lymphocytes, CytotoxicJournal Article

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G G Cross, H J Jennings, D M Whitfield, C L Penney, B Zacharie, L Gagnon. 2001. Immunostimulant oxidized beta-glucan conjugates.. https://doi.org/10.1016/s1567-5769(00)00021-7

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