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PubMed · 11370293

NMR studies on three optical active drug molecules.

E Bednarek·J C Dobrowolski·A P Mazurek
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Abstract

NMR spectroscopy is one of very few methods that enable deep insight into molecular structure and distinguishing of enantiomers. It usually requires the use of optically active agents that differentiate S and R forms through an interaction with studied molecule differentiate S and R forms. The aim of the present studies was to perform a preliminary NMR study on three chiral drugs: Fluoxetine hydrochloride, Ibuprofen, and Zolmitriptan by use of three optical solvating agents: R(-) 2,2,2-trifluoro-1-(9-anthryl)ethanol (I), (R)(+) 1,1'-bi-2-naphthol (II), and (S) tert-butyl-phenylphosphinothioic acid (III).

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Cyclooxygenase InhibitorsFluoxetineIbuprofenIsomerismMagnetic Resonance SpectroscopyOptical RotationOxazolidinonesSerotonin Receptor AgonistsSelective Serotonin Reuptake InhibitorsTryptaminesJournal ArticleResearch Support, Non-U.S. Gov't

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E Bednarek, J C Dobrowolski, A P Mazurek. NMR studies on three optical active drug molecules.. https://pubmed.ncbi.nlm.nih.gov/11370293/

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