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Oncogenic cell cycle start control.

S Jinno·J Lin·M Yageta·H Okayama
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Abstract

The ability to proliferate in the absence of anchorage is a fundamental attribute of cancer cells, yet how it is acquired is one central problem in cancer biology. By utilizing growth factor-transformable NRK cells and its insensitive mutants, we recently found that oncogenic stimulation invokes Cdk6 to participate in a critical step of the cell cycle start, but not via the regulation of its catalytic activity and that Cdk6 participation closely correlates with the anchorage-independent growth ability. Since many hematopoietic cells employ predominantly Cdk6 for the cell cycle start and perform anchorage-independent growth by nature, this finding raises the possibility that the mechanism by which oncogenic stimulation invokes anchorage-independent growth of NRK cells is similar to the one used for hematopoietic cell proliferation. We discuss this novel mechanism and its implication.

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AnimalsCell AdhesionCell CycleCell DivisionCyclin-Dependent Kinase 6Cyclin-Dependent KinasesFibroblastsHumansOncogenesProtein Serine-Threonine KinasesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S Jinno, J Lin, M Yageta, H Okayama. 2001-06-02. Oncogenic cell cycle start control.. https://doi.org/10.1016/s0027-5107(01)00092-6

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