Systematic approaches to mouse mutagenesis.

S D Brown; R Balling

doi:10.1016/s0959-437x(00)00189-1

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PubMed · 11377962

Systematic approaches to mouse mutagenesis.

S D Brown·R Balling

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Abstract

A major challenge in post-genomics is the systematic determination of mammalian gene function. A variety of mouse mutagenesis technologies, both gene- and phenotype-driven, are being used to underpin systematic and comprehensive approaches to mammalian gene function studies. Recently, a number of centres have completed large-scale ENU mutagenesis programmes that employ a phenotype-driven approach to the generation of mouse mutants. The use of ENU mutagenesis represents a powerful and efficient approach to mammalian gene-function studies, but many parallel developments are needed in downstream technologies to properly harness the new enlarged mouse-mutant resources that are being created.

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Animals Ethylnitrosourea Genetic Variation Humans Mice Mice, Mutant Strains Mutagenesis Phenotype Journal Article Review

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S D Brown, R Balling. 2001. Systematic approaches to mouse mutagenesis.. https://doi.org/10.1016/s0959-437x(00)00189-1

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