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PubMed · 11378499

Engineering human chromosomes for gene therapy studies.

K H Choo
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Abstract

We now have the capability to engineer human chromosomes that could be used to deliver therapeutic genes in gene therapy studies. These vectors have the advantages of being non-disruptive to the genome, non-immunogenic and are capable of carrying very large genes with all their regulatory sequences. What challenges lie ahead, and what future does this technology hold for gene therapy?

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K H Choo. 2001. Engineering human chromosomes for gene therapy studies.. https://doi.org/10.1016/s1471-4914(01)01951-7

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