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PubMed · 11381464

[Acute isoniazid poisoning presenting convulsion and liver dysfunction].

K Kiyota·Y Hamabe
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Abstract

A-19-year-old girl ingested 7.4 g of Isoniazid (INH) and 14.5 g of Ethambutol (EB) intentionally. She presented repetitive generalized convulsions with metabolic acidosis, treated with diazepam and 7.5 g of Pyridoxine (Vitamin B6). During day 4 and 5, liver dysfunction worsened and prothrombin time declined below 5%. She was treated with infusion of fresh frozen plasma and fully recovered on day 13. Serum concentration of INH and EB at 5 hours after ingestion was 7.6, 0.94 micrograms/ml respectively.

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Acute DiseaseAdultAntitubercular AgentsChemical and Drug Induced Liver InjuryEthambutolFemaleHumansIsoniazidPoisoningSeizuresSuicide, AttemptedCase ReportsJournal Article

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BibTeXRIS

K Kiyota, Y Hamabe. 2001. [Acute isoniazid poisoning presenting convulsion and liver dysfunction].. https://pubmed.ncbi.nlm.nih.gov/11381464/

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