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PubMed · 11382853

Decrease in muscarinic M2 receptors from synaptosomes in the pons and hippocampus after REM sleep deprivation in rats.

R J Salín-Pascual·M Díaz-Muñoz·L Rivera-Valerdi·L Ortiz-López·C Blanco-Centurión
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Abstract

The effects of both REM sleep deprivation and its recovery on pontine and hippocampus muscarinic M2 receptors were investigated in synaptosomes using [3H]-AF-DX 384 as a ligand. Animals were divided into three groups: REM sleep deprivation group (small platforms 6.5 cm of diameter); stress group (large platforms 14 cm of diameter) and cage control group. In a second experiment REM sleep-deprived animals were allowed 48 h of recovery. REM sleep-deprived rats showed a reduction in M2 receptors compared with both intact and stress groups. Changes in M2 receptors were also observed after 48 h of recovery from REM sleep deprivation only in hippocampus. The enhancement of acetylcholine release during both REM sleep deprivation and recovery could explain the present findings.

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AnimalsHippocampusMaleParasympatholyticsPirenzepinePonsRatsRats, WistarReceptor, Muscarinic M2Receptors, MuscarinicSleep DeprivationSleep, REMStress, PhysiologicalSynaptosomesJournal Article

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R J Salín-Pascual, M Díaz-Muñoz, L Rivera-Valerdi, L Ortiz-López, C Blanco-Centurión. 1998. Decrease in muscarinic M2 receptors from synaptosomes in the pons and hippocampus after REM sleep deprivation in rats.. https://pubmed.ncbi.nlm.nih.gov/11382853/

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