Understanding mucosal responsiveness: lessons from enteric bacterial pathogens.

C P Simmons; S Clare; G Dougan

doi:10.1006/smim.2001.0313

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PubMed · 11394963

Understanding mucosal responsiveness: lessons from enteric bacterial pathogens.

C P Simmons·S Clare·G Dougan

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Abstract

Mucosal immune responses must discriminate between commensal flora within the lumen and potential pathogens. These responses are highly adapted to induce protection without excessive inflammation. The balances that regulate mucosal immune and inflammatory responses have to be understood if effective mucosal immunity is to be induced through local immunization. This review will summarize some of the lessons learnt from studies of antigens derived from enteric bacterial pathogens and discuss how the gastrointestinal epithelia can 'fight back' when it encounters pathogens.

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Animals Antigens, Bacterial Bacterial Toxins Enterotoxins Escherichia coli Gastric Mucosa Humans Immune System Immunity, Mucosal Intestinal Mucosa Journal Article Review

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C P Simmons, S Clare, G Dougan. 2001. Understanding mucosal responsiveness: lessons from enteric bacterial pathogens.. https://doi.org/10.1006/smim.2001.0313

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