How does calcium trigger neurotransmitter release?

G J Augustine

doi:10.1016/s0959-4388(00)00214-2

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How does calcium trigger neurotransmitter release?

G J Augustine

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Abstract

Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.

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Animals Calcium Calcium Channels Calcium Signaling Calcium-Binding Proteins Exocytosis Humans Ion Transport Membrane Glycoproteins Nerve Endings Nerve Tissue Proteins Neurotransmitter Agents Receptors, Presynaptic Synaptic Transmission Synaptic Vesicles Synaptotagmins Journal Article Research Support, U.S. Gov't, P.H.S.Review

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G J Augustine. 2001. How does calcium trigger neurotransmitter release?. https://doi.org/10.1016/s0959-4388(00)00214-2

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