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PubMed · 11399436

Multiprotein complex signaling and the plasticity problem.

S G Grant·T J O'Dell
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Abstract

Synaptic transmission of distinct patterns of spikes, or 'neural code', leads to plastic changes in synapses and other parts of the neuron, as well as learning in animals. Recent findings indicate that specialized multiprotein structures associated with neurotransmitter receptors and cell-adhesion proteins function as molecular devices that both read the neural code and initiate long-term changes in synaptic structure and function.

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Adaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCell Adhesion MoleculesCytoskeletal ProteinsDual-Specificity PhosphatasesGTPase-Activating ProteinsHomer Scaffolding ProteinsHumansHydrogen-Ion ConcentrationIon ChannelsLong-Term PotentiationMAP Kinase Signaling SystemMacromolecular SubstancesMammalsModels, NeurologicalMultiprotein ComplexesNerve Tissue ProteinsNeuronal PlasticityNeuropeptidesPhosphoprotein PhosphatasesProtein TransportProtein-Tyrosine KinasesReceptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateReceptors, NeurotransmitterSignal TransductionSynapsesSynaptic TransmissionTwo-Hybrid System Techniquesras GTPase-Activating ProteinsJournal ArticleReview

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S G Grant, T J O'Dell. 2001. Multiprotein complex signaling and the plasticity problem.. https://doi.org/10.1016/s0959-4388(00)00220-8

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